منابع مشابه
Garlic supplements and saquinavir.
Sir—In their recent article, Piscitelli et al. [1] advise that " patients receiving saqui-navir as their sole protease inhibitor should avoid using garlic supplements " [1, p. 238]. In their study, healthy volunteers who received the antiretroviral drug sa-quinavir and a garlic supplement exhibited a significant decline in plasma levels of saquinavir. As one reason for the decline in systemic l...
متن کاملThe effect of garlic supplements on the pharmacokinetics of saquinavir.
Herbal therapies are widely used, but there are few data on their interactions with conventional medications. This study evaluated the effect of garlic supplements on the pharmacokinetics of saquinavir. Ten healthy volunteers received 10 doses of saquinavir (Fortovase) at a dosage of 1200 mg 3 times daily with meals for 4 days on study days 1-4, 22-25, and 36-39, and they received a total of 41...
متن کاملPrevention of nosocomial fungal infection: the French approach.
Sir—In their recent article, Piscitelli et al. [1] advise that " patients receiving saqui-navir as their sole protease inhibitor should avoid using garlic supplements " [1, p. 238]. In their study, healthy volunteers who received the antiretroviral drug sa-quinavir and a garlic supplement exhibited a significant decline in plasma levels of saquinavir. As one reason for the decline in systemic l...
متن کاملThe influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices.
Bioavailability and therapeutic outcome of treatment with HIV-protease inhibitors depends on intestinal and hepatic transporter-enzyme interplay. Liver transport of HIV protease inhibitors (saquinavir, darunavir) was assessed in the presence of aged garlic extract, because the HIV-infected often consume garlic supplements together with prescribed therapy. The in vitro uptake of both drugs into ...
متن کاملINVIRASE (saquinavir mesylate) CAPSULES and TABLETS Product identification in this document includes: INVIRASE in reference to saquinavir mesylate; saquinavir soft gel capsules in reference to saquinavir
DESCRIPTION INVIRASE brand of saquinavir mesylate is an inhibitor of the human immunodeficiency virus (HIV) protease. INVIRASE is available as light brown and green, opaque hard gelatin capsules for oral administration in a 200-mg strength (as saquinavir free base). Each capsule also contains the inactive ingredients lactose, microcrystalline cellulose, povidone K30, sodium starch glycolate, ta...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2002
ISSN: 1058-4838,1537-6591
DOI: 10.1086/340987